5 Topical Options for Hollow Cheeks After Weight Loss: Creams vs. Serum for a Targeted Routine

In this guide

Best match for hollow-area wording: Abib’s PDRN Volume fill-it Booster crème.

  • Abib specifically describes visible plumping of hollow areas and lists PDRN, Volufiline, retinal and peptides.
  • Adipeau and IMAGE Skincare also position creams around the appearance of lost facial fullness.
  • The Ordinary’s Volufiline product is a serum, while SkinCeuticals A.G.E. Interrupter Advanced focuses more on lines, wrinkles and discoloration.
  • These are cosmetic appearance claims, so choose by the concern and format you want to add to your routine.

If weight loss from marathon training left your cheeks and under-eyes looking scooped out, shop by the hollow-area language on the product page, not by the number of anti-wrinkle ingredients on the label. Of these five options, Abib’s PDRN Volume fill-it Booster crème is the clearest wording match: its product description directly names visible plumping of hollow areas, and it comes as a cream. Adipeau Volume Cream and IMAGE Skincare VOL.U.LIFT also make fullness-related appearance a central part of their positioning.

For this shortlist, compare each product by its maker-stated target: hollow-area appearance, weight-change appearance, or lines and skin density.

Facial appearance after weight loss can involve more than one feature. A 2026 review in Dermatologic Surgery describes facial shape as involving bone, retaining ligaments, deep and superficial fat, and skin; its focus is facial changes after GLP-1-associated weight loss. In a 2024 Dermatology Times article, plastic surgeon Rukmini Rednam describes facial volume loss and skin laxity among the secondary physical changes that can follow weight loss.

1. Adipeau Volume Cream: a targeted spot-application format

Adipeau’s Volume Cream page describes a product aimed at the appearance of fullness through the skin’s own processes. The company says to apply a thin layer to specific areas of depletion as a spot application. That direction makes the cream a practical format for someone who wants to add product only to cheeks or another targeted area rather than spread an extra cream over the entire face.

The under-eye direction is especially specific: Adipeau advises applying the cream farther from the lash line than its gel because the cream moves more. That instruction matters if you want to address both cheeks and under-eyes with one product. Adipeau’s South African listing identifies the product as Volume Cream, previously known as Active Face Cream, so shoppers searching the older name can recognize the current product naming on that page.

2. IMAGE Skincare VOL.U.LIFT: weight-change-focused face cream

IMAGE Skincare positions VOL.U.LIFT™ GLP-1 4D Skin Rebound Complex for facial appearance concerns associated with weight change. The company’s product page describes a face product for the appearance of volume loss, deep wrinkles, dehydration and diminished skin density. Its listed formula includes next-generation hyaluronic acid, biomimetic collagen fragments, bakuchiol, amino acids and XOSM Technology® antioxidants.

The brand’s VOL.U.LIFT routine guidance says to apply it to cleansed skin in the morning and evening, including the face, neck and jawline. That broader application area distinguishes it from Adipeau’s specific spot-application direction. It is the best fit here if you want a face cream whose maker directly connects its cosmetic positioning to weight-related appearance changes and whose directions include the neck and jawline as well as the face.

3. The Ordinary Volufiline: a serum for targeted areas

The Ordinary’s Volufiline 92% + Pal-Isoleucine 1% is a targeted serum for someone willing to add a serum rather than another cream. The brand’s product information says the formula is intended to plump the appearance of areas prone to looking hollow or volume-depleted, including under the eyes, cheeks and smile lines.

The Ordinary directs users to shake the serum, then apply it as needed after moisturizer directly to clean, dry target areas. The serum can be applied directly to the skin without mixing it with other products or oils.

4. SkinCeuticals A.G.E. Interrupter Advanced: more line-focused than hollow-focused

SkinCeuticals describes A.G.E. Interrupter Advanced as a whipped, creamy-balm face cream for visible signs of aging. Its product page emphasizes fine lines, wrinkles and visible discoloration, and also names skin density among its appearance concerns. The formula lists Proxylane, wild fruit flavonoids and glycyrrhetinic acid.

That profile makes A.G.E. Interrupter Advanced a reasonable candidate for someone who wants a richer cream and has lines or discoloration alongside the hollow look. SkinCeuticals distinguishes this cream from its Triple Lipid Restore 2:4:2 in the product FAQ: the latter is the product it associates with loss of facial fullness, rough texture and dullness. For a shopper focused mainly on hollow cheeks, that brand distinction matters more than the shared anti-aging category.

5. Abib PDRN Volume fill-it Booster crème: direct hollow-area language in a cream

Abib’s PDRN Volume fill-it Booster crème stands out for a direct match to the appearance goal in this brief. Abib describes it as a targeted booster crème formulated with PDRN, Volufiline, retinal and peptides, and says it helps visibly plump hollow areas while improving the look of wrinkles, firmness and elasticity. The product description states PDRN at 15,000 ppm and Volufiline at 10,000 ppm.

How the five options differ

Product Format Maker-stated cosmetic focus Directions or formula detail that helps you choose
Adipeau Volume Cream, formerly Active Face Cream Cream Appearance of fullness in targeted areas Thin layer on specific areas; apply farther from the lash line around the eyes.
IMAGE Skincare VOL.U.LIFT GLP-1 4D Skin Rebound Complex Face cream Appearance of volume loss, deep wrinkles, dehydration and diminished density, including changes associated with GLP-1 use Maker’s routine applies it to the face, neck and jawline morning and evening.
The Ordinary Volufiline 92% + Pal-Isoleucine 1% Targeted serum Plumping appearance of hollow-prone areas, including cheeks and under-eyes Shake and apply after moisturizer to clean, dry areas; no mixing needed.
SkinCeuticals A.G.E. Interrupter Advanced Cream Fine lines, wrinkles, discoloration and skin density Whipped creamy-balm texture; SkinCeuticals assigns facial-fullness language to its separate Triple Lipid Restore 2:4:2 cream.
Abib PDRN Volume fill-it Booster crème Booster crème Visible plumping of hollow areas plus the look of wrinkles, firmness and elasticity PDRN 15,000 ppm and Volufiline 10,000 ppm; includes retinal and peptides.

The clearest fits for hollow-area language are Abib, Adipeau, IMAGE and The Ordinary. The last one is the serum; the other three are cream-format products. SkinCeuticals is the better match when wrinkle appearance, discoloration or skin density matter as much as the hollow look.

Pick by the one change you want to prioritize

  • Choose Abib if you want a cream whose product description explicitly names visible plumping of hollow areas, plus retinal and peptides in the formula.
  • Choose Adipeau if you prefer a spot-application cream and want the maker’s direction for targeted cheek or under-eye use.
  • Choose IMAGE Skincare if you want a face cream positioned for weight-change appearance and prefer directions that include the face, neck and jawline.
  • Choose The Ordinary if a serum suits your routine and you want a product that goes directly on clean, dry target areas after your moisturizer.
  • Choose SkinCeuticals A.G.E. Interrupter Advanced if wrinkles, fine lines and discoloration are prominent priorities alongside your interest in skin density.

If you add just one leave-on this month, put Abib first on the list because its product description speaks to scooped-looking cheeks and under-eyes in a cream format.

FAQ

Can a topical cream restore the facial volume I lost while running?

These products describe cosmetic appearance goals, such as fuller-looking skin or visible plumping in hollow areas. For questions about a pronounced or persistent change in facial contour, ask a qualified skin professional to explain which options fit your situation.

Should I put The Ordinary Volufiline serum before or after moisturizer?

After moisturizer. The Ordinary instructs users to apply it to clean, dry target areas after moisturizer, and says it does not need to be mixed with another product or oil.

Which option is a serum rather than a cream?

The Ordinary Volufiline 92% + Pal-Isoleucine 1% is the serum. Adipeau Volume Cream, IMAGE Skincare VOL.U.LIFT and SkinCeuticals A.G.E. Interrupter Advanced are creams, while Abib names its product a booster crème.

How should I distinguish a hollow-looking cheek from dehydration?

A hollow appearance describes a contour; dehydration more often appears as tightness, dullness, uneven texture or temporary fine lines. NIOD’s guide says temporary dehydration lines can improve with proper hydration, so address dry-surface signs through your moisturizer routine while choosing a targeted product by its own hollow-area wording.

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